Membrane-Bound Form Soluble Form Is More Effective Than the Expressed by Thymic Epithelial Cells: The T Cell Tolerance to a Neo-Self Antigen
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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
Central tolerance is shaped by the array of self-antigens expressed and presented by various types of thymic antigen-presenting cells (APCs). Depending on the overall signal quality and/or quantity delivered in these interactions, self-reactive thymocytes either apoptose or commit to the T regulatory cell lineage. The cellular and molecular complexity underlying these events has only recently b...
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تاریخ انتشار 2003